https://peertube.dngr.us/videos/watch/1f2f7b9b-6b08-4b4f-b56e-e8ad6348ab40 Join this channel to get access to perks: https://www.youtube.com/channel/UCddem5RlB3bQe99wyY49g0g/join Want to learn more about Periscope Film and get access to exclusive swag? Join us on Patreon. Visit https://www.patreon.com/PeriscopeFilm Visit our website www.PeriscopeFilm.com This 1966 color educational film by International Film Bureau Inc. shows clinical case studies and observations from Dr. Richard Koch at Los Angeles Children’s Hospital (CHLA) on children with Phenylketonuria (PKU), an inherited condition that causes a buildup of phenylalanine, an amino acid, in the body. PKU causes a form of mental retardation that can be prevented with a low-protein diet. Produced by Carl J. Ross. The film begins with two nurses handing toys to a child with PKU strapped into a stander (0:49). He makes writhing movements and has difficulty holding his head up. A mother holds a baby with PKU whose head is enlarged (1:13). Dr. Koch, from the Child Development Division at CHLA, examines a young child with PKU, raising his arms above his head (1:44). A 4-year-old with PKU and estimated IQ of 11 walks unsteadily (2:01); associated signs of PKU include eczema, mild seizures, blonde hair, and blue eyes. The child has red hair and brown eyes and sits in a high chair while a caregiver tries to feed him, waving his arms and rocking (2:50). Narration explains that until recently, the average age of diagnosis was between 2 to 3 years, usually because of a similarly-affected sibling. This delay means that retardation has already set in and treatment is less effective. PKU was first identified in 1934 by Dr. Ivar Asbjorn Folling in Norway, and is caused by a defect in a liver enzyme that changes phenylalanine to tyrosine. A doctor examines a 1-year-old with PKU and moderate retardation (4:05). An 8-month-old with PKU kicks his legs on a blanket; he is unable to roll over or sit up (4:50). The same child at 2.5 years old (5:35) stacks blocks and is more responsive to his environment after being started on a special diet. The child plays with shape toys (7:00) and a book while narration explains that CHLA screens infants for PKU with a blood test; if identified early, they can be started on the diet and retardation prevented. An infant diagnosed with PKU at 6 weeks by Dr. Joseph Garrisi (7:47); she appears normal in all aspects. At 7 months (8:00), she babbles and plays with blocks. At 11 months (8:30), she sits in a chair, picks up a bell, and looks at herself in a mirror. She uses Lofenalac, a low-phenylalanine formula developed in the 1950s, to prevent effects of PKU (9:10). Lofenalac is shown next to a bottle of milk (9:30). The child creeps and pulls herself to standing (9:48). Dr. Koch shows her a picture book (10:05). At 18 months (10:08), she plays with a shape puzzle, puts beads in a bottle, and plays with a ball. Narration discusses the importance of early screening and diagnosis. She stands and sits from a bench (11:27). The best prognosis comes if a child is diagnosed in the first 5 weeks of life. At 3 years old (11:48), in a video from the Hospital for Sick Children in Toronto, the child sits at a desk and plays with a doll on a rocking horse (12:05); she has a normal IQ. She draws at a board on the wall (12:20). Nutritionists, public health nurses, and social workers are key in PKU treatment. A doctor examines an infant in an incubator (12:51). A nurse pricks its heel as part of the Guthrie blood test for PKU (12:59). At a processing center, a female technician spins blood samples in a centrifuge (13:30). A tester dips a Phenistik in urine to determine if feel pyretic acid is present (14:00). A nutritionist feeds a child with PKU (14:46). Children with PKU pass a car back and forth (15:12). Some film sequences supplied by Dr. Joseph Garrisi and Dr. Willard Centerwall, Hospital for Sick Children, Toronto. Larry Dandall, Productions. Phenylketonuria, also called PKU, is a rare inherited disorder that causes an amino acid called phenylalanine to build up in the body. PKU is caused by a change in the phenylalanine hydroxylase (PAH) gene. This gene helps create the enzyme needed to break down phenylalanine. Motion picture films don't last forever; many have already been lost or destroyed. For almost two decades, we've worked to collect, scan and preserve the world as it was captured on 35mm, 16mm and 8mm movies -- including home movies, industrial films, and other non-fiction. If you have endangered films you'd like to have scanned, or wish to donate celluloid to Periscope Film so that we can share them with the world, we'd love to hear from you. Contact us via the weblink below. This film is part of the Periscope Film LLC archive, one of the largest historic military, transportation, and aviation stock footage collections in the USA. Entirely film backed, this material is available for licensing in 24p HD, 2k and 4k. For more information visit http://www.PeriscopeFilm.com Source: https://www.youtube.com/watch?v=FCfH6vhA96k Mirrored from Periscope Film (https://www.youtube.com/@PeriscopeFilm) Sat, 13 Jun 2026 13:15:43 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://peertube.dngr.us https://peertube.dngr.us/lazy-static/avatars/41a6fee9-7f57-42d0-a5fc-5db4f1af2e31.png https://peertube.dngr.us/videos/watch/1f2f7b9b-6b08-4b4f-b56e-e8ad6348ab40 All rights reserved, unless otherwise specified in the terms specified at https://peertube.dngr.us/about and potential licenses granted by each content's rightholder.